张家口市第一医院消化内二科;张家口市第一医院外科;
目的 探讨结差分化细胞群(PDCs)与直肠癌患者根治术后发生隐匿性肝转移的关系。方法 回顾性分析2020年7月至2022年7月在张家口市第一医院接受结直肠癌根治术患者的临床病历资料，共纳入185例。采用病理HE染色检测患者的PDCs分级，分析PDCs分级与结直肠癌临床病理特征的关系。术后随访12～36个月，根据是否发生隐匿肝转移分为转移组(n=46)和未转移组(n=139),比较两组临床资料，采用Logistic回归模型分析影响结直肠癌术后发生隐匿性肝转移的危险因素。结果 185例结直肠癌组织中G1级37例、G2级78例和G3级70例。PDCs级别与性别、年龄、肿瘤直径、肿瘤位置、有无腹腔积液及有无肠穿孔等均无关(P>0.05);PDCs级别与周围神经侵犯、淋巴结转移、分化程度、血管侵犯和病理T分期等均有关(P<0.05)。转移组患者肿瘤直径≥5 cm、有周围神经侵犯、有淋巴结转移、低分化程度、有血管侵犯、T3-4期及PDCs级别G3级比例高于未转移组，差异有统计学意义(P<0.05)。多因素Logistic回归模型结果显示，淋巴结转移、血管侵犯、周围神经侵犯和PDCs级别是影响患者发生隐匿性肝转移的危险因素(P<0.05)。结论 结直肠癌组织中PDCs分级与周围神经侵犯、淋巴结转移、分化程度、血管侵犯和病理T分期有关，且有淋巴结转移、血管侵犯、周围神经侵犯和PDCs级别G3级是影响结直肠癌患者发生隐匿性肝转移的危险因素。
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基本信息:
DOI：
中图分类号:R735.34
引用信息:
[1]张学君,李南阳,王峰等.差分化细胞群与结直肠癌术后隐匿性肝转移关系的临床观察[J].临床肿瘤学杂志,2025,30(03):215-219.
基金信息:
张家口市科技计划资助项目(KY20211063)