临床肿瘤学杂志

目的 探讨超声引导下淋巴结粗针穿刺活检在淋巴瘤诊断及分型中的价值。方法 回顾性收集2022年1月至2023年12月在江苏省肿瘤医院收治的131例疑似淋巴瘤患者，根据取材方法分为超声下穿刺活检组与手术切除活检组，其中超声下穿刺活检组64例，手术切除活检组67例，比较超声下穿刺活检组和手术切除活检组淋巴瘤首次取材的病理诊断结果、总诊断准确率以及不良反应情况。同时分析超声下穿刺活检组和手术切除活检组对不同部位非霍奇金淋巴瘤的诊断效能，组内比较分析超声下穿刺活检组对不同大小淋巴瘤的诊断效能。结果 超声下穿刺活检组首次取材总诊断准确率(90.63%)与手术切除活检组(88.06%)差异无统计学意义(P>0.05);超声下穿刺活检组病理分型为55例非霍奇金淋巴瘤、霍奇金淋巴瘤3例，手术切除活检组的霍奇金淋巴瘤为3例，非霍奇金淋巴瘤为56例，两组差异无统计学意义(P>0.05);超声下穿刺活检组浅表非霍奇金淋巴瘤的诊断率(98.00%)与手术切除活检组(97.92%)差异无统计学意义(P>0.05);超声下穿刺活检组深部非霍奇金淋巴瘤的诊断率(80.00%)与手术切除活检组(87.50%)差异无统计学意义(P>0.05);超声下穿刺活检组不良反应发生率(3.16%)与手术切除活检组(13.43%)差异有统计学意义(P<0.05);超声下穿刺活检组内4个亚组间诊断率差异无统计学意义(P>0.05)。结论 超声引导下淋巴结粗针穿刺活检有助于淋巴瘤的诊断及分型，且操作相对简单快捷，安全性较高，适宜广泛应用于临床淋巴瘤的诊断。

Objective To explore the value of ultrasound-guided core needle biopsy of lymph nodes in the diagnosis and classification of lymphoma. Methods A total of 131 suspected lymphoma patients admitted to Jiangsu Cancer Hospital from January 2022 to December 2023 were retrospectively collected and divided into two groups according to sampling methods: ultrasound biopsy group and surgical biopsy group, including 64 cases in the ultrasound biopsy group and 67 cases in the surgical biopsy group. The pathological diagnosis results, total diagnostic accuracy and adverse reactions were compared between the ultrasound biopsy group and the surgical excision biopsy group. At the same time, the diagnostic efficacy of ultrasonic puncture biopsy group and surgical resection biopsy group for different sites of non-Hodgkin lymphoma was analyzed, and the diagnostic efficacy of ultrasonic puncture biopsy group for different sizes of lymphoma was compared within the group. Results There was no significant difference in the total diagnostic accuracy of first sampling between the ultrasound biopsy group and the surgical excision biopsy group(P>0.05). There were 55 cases of non-Hodgkin lymphoma and 3 cases of Hodgkin lymphoma in the ultrasound biopsy group, and 3 cases of Hodgkin lymphoma and 56 cases of non-Hodgkin lymphoma in the surgical resection biopsy group, with no statistical significance between the two groups(P>0.05). There was no significant difference in the diagnosis rate of superficial non-Hodgkin lymphoma between the ultrasound biopsy group and the surgical biopsy group(P>0.05). There was no significant difference in the diagnosis rate of deep non-Hodgkin lymphoma between the ultrasound biopsy group and the surgical biopsy group(P>0.05). The incidence of adverse reactions in the ultrasound biopsy group was significantly different from that in the surgical resection biopsy group(P<0.05). There was no significant difference in diagnostic rate among the 4 subgroups in the ultrasound biopsy group(P>0.05). Conclusion Ultrasound-guided lymph node coarse needle biopsy is helpful for the diagnosis and classification of lymphoma, and the operation is relatively simple and fast, with high safety, which is suitable for widely used in clinical diagnosis of lymphoma.